Novye transformacii analogov oxazolo[3,2-a] piridiniya

Odnoj iz vazhnejshih osobennostej geterociklicheskih soedinenij yavlyaetsya ih sposobnost k reciklizaciyam. Peregruppirovki geterociklicheskih kolec privodyat k neozhidannym produktam, prohodyat po slozhnym, stupenchatym mehanizmam i obladajut ogromnym sinteticheskim potencialom, t.k. otkryvajut dostup ko mnogim novym klassam soedinenij. Dannaya rabota posvyashhena sintezu i izucheniju reakcij s nukleofilami kationoidnyh biciklicheskih sistem s mostikovym atomom azota, postroennyh na osnove sochleneniya ciklov azolov i azinov, t.e. geteroanalogov indolizina. Te svedeniya o predstavitelyah jetogo klassa, kotorye mozhno najti v literature, pozvolyajut predpolagat nalichie vysokoj reakcionnoj sposobnosti po otnosheniju k nukleofilnoj atake. Jeto ob#yasnyaetsya nalichiem neskolkih reakcionnyh centrov srazu v oboih ciklah, i pojetomu predstaviteli jetogo klassa geterociklicheskih soedinenij sposobny vstupat v reakcii zatragivajushhie kak pyati-, tak i shestichlennye fragmenty. Mezhdu tem, nesmotrya na vsju svoju potencialnuju privlekatelnost, klass kationoidnyh azoloazinov s mostikovym atomom azota do sih por ostaetsya maloizuchennym. Rassmotreny tia- i aza-analogi oxazolo-piridiniya, mono-, bi- i tri-ciklicheskie proizvodnye.

oxazole The Fischer oxazole synthesis is a type of Dehydration reaction which can occur under mild conditions in a rearrangement of the groups that would not seem possible. The reaction occurs by dissolving the reactants in dry ether and passing through the solution dry, gaseous [1,3]Oxazolo[4,5-b]pyridin-2(3H)-one | C6H4N2O2 | …